GLP-1 Before & After: Real Results Timeline
What weight loss actually looks like month by month on GLP-1 — based on clinical trial data and real-world outcomes.
Typical Responder Timeline
For a starting weight of 220 lbs on Wegovy:
| Time | Weight Lost | Total Loss | % of Body Weight |
|---|---|---|---|
| Week 4 | 5-7 lbs | 5-7 lbs | ~3% |
| Month 2 | +5 lbs | 10-12 lbs | ~5% |
| Month 3 | +5 lbs | 15-17 lbs | ~7% |
| Month 6 | +15 lbs | 30-35 lbs | ~14% |
| Month 12 | +10 lbs | 40-45 lbs | ~20% |
| Month 18 | +3 lbs | ~48 lbs | ~22% |
Percentile Outcomes (Wegovy STEP-1)
- Average loss: 14.9%
- Top 10% responders: ≥25%
- Top 25% responders: ≥18%
- Median: ~14%
- Bottom 25% responders: ~7%
- Bottom 10% (non-responders): under 5%
Tirzepatide (Zepbound) results are 5-7 percentage points higher across each band.
Frequently Asked Questions
Average weight loss on GLP-1 by month?
Month 1: ~5-7 lbs. Month 2: 8-12 lbs total. Month 3: 12-17 lbs. Month 6: 20-30 lbs. Month 12: 30-50+ lbs. These are typical responder numbers; individual results vary.
How long until I see GLP-1 results?
Visible appetite changes start in week 1-2. Visible weight loss starts at week 4-8. Friends/family typically notice at month 3-4.