FDA Approved

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Real Liraglutide prescribed by licensed US clinicians. ~5-8% body weight body weight on average. First-generation daily GLP-1. Brand names: Saxenda, Victoza. Now available as generic.

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Avg weight loss

~5-8%

Cost

$450-1,400/mo

Dosing

Once daily

FDA Status

Weight Loss

Liraglutide is a first-generation GLP-1 receptor agonist approved as Saxenda for weight loss and Victoza for type 2 diabetes. It requires daily subcutaneous injection. As of 2024, generic liraglutide is available, dropping the cost by roughly 70%.

Overview

Liraglutide was developed by Novo Nordisk, with Victoza approved in 2010 for type 2 diabetes and Saxenda approved in 2014 for weight loss. It was the first long-acting GLP-1 with sufficient half-life (~13 hours) for once-daily dosing — a significant improvement over earlier options like exenatide. The first authorized generic version of liraglutide launched in late 2024.

How Liraglutide Works

Liraglutide is a 31-amino-acid peptide modeled on GLP-1, with a fatty-acid linker that binds to albumin. Same mechanisms as semaglutide (appetite suppression, slowed gastric emptying, glucose-dependent insulin, glucagon suppression) but with daily dosing required.

Dosing & Schedule

Saxenda titration over 5 weeks:

Week 1: 0.6 mg daily
Week 2: 1.2 mg daily
Week 3: 1.8 mg daily
Week 4: 2.4 mg daily
Week 5+: 3.0 mg daily (maintenance)

Victoza maximum is 1.8 mg daily for diabetes.

Effectiveness — Trial Data

SCALE trial (Saxenda 3.0 mg, 56 weeks): 5-8% average weight loss vs. 2.6% placebo. Less effective than semaglutide or tirzepatide but more affordable in generic form.

Side Effects

Common: nausea (40%), diarrhea (21%), vomiting (16%), constipation (19%), headache (14%), fatigue (8%). Most GI effects peak in early weeks and improve.

Cost — How Much Liraglutide Costs in 2026

Liraglutide pricing:

Saxenda brand: $1,349/mo
Victoza brand: $815-1,200/mo
Generic liraglutide: ~$450/mo (launched late 2024)

Who Is Liraglutide For?

FDA-approved for chronic weight management (Saxenda) in adults BMI ≥30, or ≥27 with comorbidity, and pediatric ≥12 with high BMI. Victoza is approved for type 2 diabetes including pediatric ≥10.

Liraglutide Alternatives

Alternatives: Semaglutide (weekly, stronger results), Tirzepatide.

Frequently Asked Questions

Is liraglutide a GLP-1?

Yes. Liraglutide is a first-generation GLP-1 receptor agonist. It is the active ingredient in Saxenda and Victoza.

How does liraglutide compare to semaglutide?

Same drug class but different molecules. Liraglutide is daily; semaglutide is weekly. Semaglutide produces about double the weight loss in trials.

Is generic liraglutide available?

Yes — the first authorized generic launched in late 2024 at significantly lower price than Saxenda/Victoza brand.