Dulaglutide (dulaglutide)
Active ingredient in Trulicity. No generic yet available.
Dulaglutide is the active ingredient in Trulicity, a once-weekly GLP-1 receptor agonist by Eli Lilly. It is approved for type 2 diabetes and cardiovascular risk reduction.
Overview
Dulaglutide is a fusion protein combining a modified GLP-1 sequence with a human IgG4 antibody fragment. The Fc fragment extends half-life to about 5 days, enabling once-weekly dosing. It is currently brand-only (Trulicity) — no generic or compounded version available.
How Dulaglutide Works
Standard GLP-1 receptor agonist mechanism. Less potent than semaglutide molecule-for-molecule.
Dosing & Schedule
Same as Trulicity: 0.75, 1.5, 3.0, or 4.5 mg/week.
Effectiveness — Trial Data
A1c reduction 1.0-1.5%, weight loss 3-5 kg as side benefit.
Side Effects
Standard GLP-1 GI profile, generally well tolerated.
Cost — How Much Dulaglutide Costs in 2026
Trulicity is the only commercially available form: $987/mo list. No generic available.
Who Is Dulaglutide For?
Adults and children 10+ with type 2 diabetes.
Dulaglutide Alternatives
Alternatives: semaglutide (Ozempic), tirzepatide (Mounjaro), liraglutide (Victoza/generic).