:root{--c-primary: #1e40af;--c-primary-2: #3b82f6;--c-primary-50: #eff6ff;--c-primary-100: #dbeafe;--c-primary-700: #1d4ed8;--c-cta: #f43f5e;--c-cta-700: #be123c;--c-bg: #ffffff;--c-bg-alt: #f8fafc;--c-text: #0f172a;--c-text-muted: #475569;--c-text-mute2: #64748b;--c-border: #e2e8f0;--c-border-2: #cbd5e1;--c-star: #fbbf24;--c-tool-bg: #eff6ff;--c-success: #16a34a;--c-warn: #d97706;--c-danger: #dc2626;--shadow-sm: 0 1px 2px rgba(15,23,42,.06);--shadow-md: 0 4px 12px rgba(15,23,42,.08);--shadow-lg: 0 10px 32px rgba(15,23,42,.1);--r-sm: 6px;--r: 10px;--r-lg: 16px;--r-xl: 22px;--container: 1180px;--container-narrow: 880px;--font-sans: ui-sans-serif, system-ui, -apple-system, "Segoe UI", Roboto, Inter, sans-serif;--font-serif: "Georgia", "Iowan Old Style", "Times New Roman", serif}*{box-sizing:border-box}html{-webkit-text-size-adjust:100%;scroll-behavior:smooth}body{margin:0;font-family:var(--font-sans);color:var(--c-text);background:var(--c-bg);line-height:1.65;font-size:17px;-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}img,svg,video{max-width:100%;height:auto;display:block}a{color:var(--c-primary-700);text-decoration:underline;text-underline-offset:2px;text-decoration-thickness:1px}a:hover{color:var(--c-cta)}h1,h2,h3,h4{font-family:var(--font-sans);line-height:1.2;color:var(--c-text);margin:1.6em 0 .6em;font-weight:700;letter-spacing:-.01em}h1{font-size:clamp(2rem,4.6vw,3rem);margin-top:0;letter-spacing:-.025em}h2{font-size:clamp(1.55rem,3vw,2.1rem)}h3{font-size:1.3rem}h4{font-size:1.1rem}p{margin:0 0 1em}hr{border:0;height:1px;background:var(--c-border);margin:2.5rem 0}.container{max-width:var(--container);margin:0 auto;padding:0 20px}.container-narrow{max-width:var(--container-narrow);margin:0 auto;padding:0 20px}.section{padding:64px 0}.section--alt{background:var(--c-bg-alt)}.section--cta{background:linear-gradient(135deg,var(--c-primary) 0%,#2563eb 100%);color:#fff}.section--cta h2,.section--cta h3{color:#fff}.prose{font-size:1.05rem}.prose ul,.prose ol{padding-left:1.4em;margin:0 0 1em}.prose li{margin:.35em 0}.prose blockquote{border-left:4px solid var(--c-primary-2);margin:1.4em 0;padding:.6em 1.2em;background:var(--c-primary-50);color:var(--c-text);font-style:italic;border-radius:0 var(--r) var(--r) 0}.prose table{width:100%;border-collapse:collapse;margin:1.4em 0;font-size:.96em}.prose th,.prose td{border:1px solid var(--c-border);padding:10px 14px;text-align:left}.prose th{background:var(--c-primary-50);font-weight:600}.prose tr:nth-child(2n) td{background:var(--c-bg-alt)}.prose code{background:var(--c-bg-alt);padding:2px 6px;border-radius:4px;font-size:.92em}.btn{display:inline-block;background:var(--c-cta);color:#fff!important;padding:14px 28px;border-radius:var(--r);text-decoration:none;font-weight:700;font-size:1rem;border:0;cursor:pointer;transition:transform .15s ease,box-shadow .15s ease,background .15s ease;box-shadow:var(--shadow-sm);letter-spacing:-.005em}.btn:hover{background:var(--c-cta-700);transform:translateY(-1px);box-shadow:var(--shadow-md);color:#fff!important}.btn--lg{padding:18px 36px;font-size:1.1rem}.btn--xl{padding:20px 44px;font-size:1.2rem}.btn--ghost{background:transparent;color:var(--c-primary-700)!important;border:2px solid var(--c-primary)}.btn--ghost:hover{background:var(--c-primary);color:#fff!important}.btn--block{display:block;width:100%;text-align:center}.card{background:#fff;border:1px solid var(--c-border);border-radius:var(--r-lg);padding:24px;box-shadow:var(--shadow-sm);transition:box-shadow .2s ease,transform .2s ease}.card:hover{box-shadow:var(--shadow-md)}.card h3{margin-top:0}.grid{display:grid;gap:20px}.grid--2{grid-template-columns:repeat(2,1fr)}.grid--3{grid-template-columns:repeat(3,1fr)}.grid--4{grid-template-columns:repeat(4,1fr)}@media(max-width:900px){.grid--3,.grid--4{grid-template-columns:repeat(2,1fr)}}@media(max-width:600px){.grid--2,.grid--3,.grid--4{grid-template-columns:1fr}}.badge{display:inline-block;padding:4px 10px;border-radius:999px;font-size:.78rem;font-weight:600;text-transform:uppercase;letter-spacing:.03em;background:var(--c-primary-50);color:var(--c-primary-700)}.badge--fda{background:#dcfce7;color:#166534}.badge--pipeline{background:#fef3c7;color:#92400e}.badge--supp{background:#fce7f3;color:#9d174d}.badge--gen{background:#e0e7ff;color:#3730a3}.badge--off{background:#fee2e2;color:#991b1b}.stars{display:inline-flex;gap:2px;color:var(--c-star);font-size:1.1rem;line-height:1;vertical-align:middle}.stars--lg{font-size:1.4rem}.hero{background:linear-gradient(180deg,var(--c-primary-50) 0%,#fff 100%);padding:72px 0 56px;text-align:center}.hero h1{max-width:880px;margin:0 auto 16px}.hero .lede{font-size:1.2rem;color:var(--c-text-muted);max-width:700px;margin:0 auto 28px}.hero__cta-row{display:flex;gap:14px;justify-content:center;flex-wrap:wrap}.cta-box{background:linear-gradient(135deg,var(--c-primary) 0%,#2563eb 100%);color:#fff;padding:36px;border-radius:var(--r-lg);text-align:center;margin:2em 0;box-shadow:var(--shadow-md)}.cta-box h3{color:#fff;margin-top:0}.cta-box p{color:#dbeafe;margin-bottom:1.4em}.tool-box{background:var(--c-tool-bg);border:2px solid var(--c-primary-2);border-radius:var(--r-lg);padding:28px;margin:2em 0}.tool-box label{display:block;font-weight:600;margin:12px 0 6px}.tool-box select,.tool-box input[type=text],.tool-box input[type=number]{width:100%;padding:10px 12px;border:1px solid var(--c-border-2);border-radius:var(--r-sm);font-size:1rem;background:#fff}.tool-box .result{margin-top:18px;padding:16px;background:#fff;border-radius:var(--r);border:1px solid var(--c-border)}.crumbs{font-size:.9rem;color:var(--c-text-mute2);padding:18px 0 0}.crumbs a{color:var(--c-text-mute2);text-decoration:none}.crumbs a:hover{color:var(--c-primary);text-decoration:underline}.crumbs span{margin:0 6px}.toc{background:var(--c-bg-alt);border-left:4px solid var(--c-primary-2);padding:18px 22px;margin:1.5em 0;border-radius:0 var(--r) var(--r) 0}.toc h4{margin-top:0;font-size:.95rem;text-transform:uppercase;letter-spacing:.05em;color:var(--c-text-muted)}.toc ul{margin:0;padding-left:1.2em}.toc li{margin:.25em 0}.stat-card{display:grid;grid-template-columns:repeat(4,1fr);gap:0;background:#fff;border:1px solid var(--c-border);border-radius:var(--r-lg);overflow:hidden;margin:2em 0;box-shadow:var(--shadow-sm)}.stat-card>div{padding:20px;text-align:center;border-right:1px solid var(--c-border)}.stat-card>div:last-child{border-right:0}.stat-card .label{font-size:.78rem;text-transform:uppercase;color:var(--c-text-mute2);letter-spacing:.04em}.stat-card .value{font-size:1.4rem;font-weight:700;color:var(--c-primary);margin-top:4px}@media(max-width:700px){.stat-card{grid-template-columns:repeat(2,1fr)}.stat-card>div{border-bottom:1px solid var(--c-border)}}details.faq{background:#fff;border:1px solid var(--c-border);border-radius:var(--r);margin:10px 0;padding:0;box-shadow:var(--shadow-sm)}details.faq summary{cursor:pointer;padding:16px 44px 16px 20px;font-weight:600;color:var(--c-text);list-style:none;position:relative}details.faq summary::-webkit-details-marker{display:none}details.faq summary:after{content:"+";position:absolute;right:18px;top:50%;transform:translateY(-50%);font-size:1.5rem;color:var(--c-primary);font-weight:400}details.faq[open] summary:after{content:"−"}details.faq div.faq-body{padding:0 20px 18px;color:var(--c-text-muted)}.skip-link{position:absolute;left:-9999px;top:0;background:var(--c-primary);color:#fff;padding:10px 16px;z-index:1000}.skip-link:focus{left:8px;top:8px}.text-center{text-align:center}.mt-0{margin-top:0}.mb-0{margin-bottom:0}.muted{color:var(--c-text-muted)}.site-header[data-astro-cid-3ef6ksr2]{position:sticky;top:0;z-index:100;background:#fff;border-bottom:1px solid var(--c-border);box-shadow:var(--shadow-sm)}.site-header__inner[data-astro-cid-3ef6ksr2]{display:flex;align-items:center;gap:28px;padding:14px 20px}.brand[data-astro-cid-3ef6ksr2]{display:flex;align-items:center;gap:10px;text-decoration:none;color:var(--c-text);font-weight:800;font-size:1.2rem;letter-spacing:-.02em}.brand__text-light[data-astro-cid-3ef6ksr2]{color:var(--c-primary);font-weight:600}.brand[data-astro-cid-3ef6ksr2]:hover{color:var(--c-primary)}.meganav[data-astro-cid-3ef6ksr2]{flex:1}.meganav__list[data-astro-cid-3ef6ksr2]{display:flex;gap:4px;list-style:none;margin:0;padding:0;justify-content:center}.meganav__item[data-astro-cid-3ef6ksr2]{position:relative}.meganav__btn[data-astro-cid-3ef6ksr2]{background:none;border:0;padding:10px 14px;cursor:pointer;color:var(--c-text);font-weight:600;font-size:.98rem;font-family:inherit;display:flex;align-items:center;gap:6px;border-radius:var(--r-sm)}.meganav__btn[data-astro-cid-3ef6ksr2]:hover,.meganav__item[data-astro-cid-3ef6ksr2]:hover .meganav__btn[data-astro-cid-3ef6ksr2]{background:var(--c-primary-50);color:var(--c-primary-700)}.meganav__panel[data-astro-cid-3ef6ksr2]{position:absolute;top:100%;left:0;min-width:230px;background:#fff;border:1px solid var(--c-border);border-radius:var(--r);box-shadow:var(--shadow-lg);padding:10px;opacity:0;visibility:hidden;transform:translateY(6px);transition:opacity .15s,transform .15s,visibility .15s;z-index:50}.meganav__item[data-astro-cid-3ef6ksr2]:hover .meganav__panel[data-astro-cid-3ef6ksr2],.meganav__item[data-astro-cid-3ef6ksr2]:focus-within .meganav__panel[data-astro-cid-3ef6ksr2]{opacity:1;visibility:visible;transform:translateY(0)}.meganav__panel[data-astro-cid-3ef6ksr2] ul[data-astro-cid-3ef6ksr2]{list-style:none;margin:0;padding:0}.meganav__panel[data-astro-cid-3ef6ksr2] a[data-astro-cid-3ef6ksr2]{display:block;padding:8px 12px;color:var(--c-text);text-decoration:none;border-radius:var(--r-sm);font-size:.94rem}.meganav__panel[data-astro-cid-3ef6ksr2] a[data-astro-cid-3ef6ksr2]:hover{background:var(--c-primary-50);color:var(--c-primary-700)}.btn--header[data-astro-cid-3ef6ksr2]{padding:10px 16px;font-size:.92rem}.hamburger[data-astro-cid-3ef6ksr2]{display:none;background:none;border:0;padding:8px;cursor:pointer;flex-direction:column;gap:4px}.hamburger[data-astro-cid-3ef6ksr2] span[data-astro-cid-3ef6ksr2]{display:block;width:24px;height:2.5px;background:var(--c-text);border-radius:2px}.mobile-menu[data-astro-cid-3ef6ksr2]{display:none}.mobile-menu__group[data-astro-cid-3ef6ksr2]{padding:16px 0;border-bottom:1px solid var(--c-border)}.mobile-menu__label[data-astro-cid-3ef6ksr2]{font-weight:700;font-size:.85rem;text-transform:uppercase;letter-spacing:.05em;color:var(--c-primary);margin-bottom:8px}.mobile-menu[data-astro-cid-3ef6ksr2] ul[data-astro-cid-3ef6ksr2]{list-style:none;margin:0;padding:0}.mobile-menu[data-astro-cid-3ef6ksr2] a[data-astro-cid-3ef6ksr2]{display:block;padding:8px 0;color:var(--c-text);text-decoration:none}@media(max-width:1024px){.meganav[data-astro-cid-3ef6ksr2],.btn--header[data-astro-cid-3ef6ksr2]{display:none}.hamburger[data-astro-cid-3ef6ksr2]{display:flex}.mobile-menu[data-astro-cid-3ef6ksr2][data-open]{display:block;padding:14px 0 28px;border-top:1px solid var(--c-border);background:#fff}}.site-footer[data-astro-cid-sz7xmlte]{background:#0f172a;color:#cbd5e1;padding:56px 0 24px;margin-top:80px}.footer-grid[data-astro-cid-sz7xmlte]{display:grid;grid-template-columns:1.4fr repeat(4,1fr);gap:36px;padding-bottom:36px;border-bottom:1px solid #1e293b}.footer-brand[data-astro-cid-sz7xmlte]{color:#fff;font-weight:800;font-size:1.4rem;margin-bottom:10px;letter-spacing:-.02em}.footer-tag[data-astro-cid-sz7xmlte]{color:#94a3b8;margin-bottom:18px;font-size:.95rem}.site-footer[data-astro-cid-sz7xmlte] h4[data-astro-cid-sz7xmlte]{color:#fff;font-size:.85rem;text-transform:uppercase;letter-spacing:.07em;margin:0 0 14px}.site-footer[data-astro-cid-sz7xmlte] ul[data-astro-cid-sz7xmlte]{list-style:none;margin:0;padding:0}.site-footer[data-astro-cid-sz7xmlte] ul[data-astro-cid-sz7xmlte] li[data-astro-cid-sz7xmlte]{margin:6px 0}.site-footer[data-astro-cid-sz7xmlte] a[data-astro-cid-sz7xmlte]{color:#cbd5e1;text-decoration:none;font-size:.94rem}.site-footer[data-astro-cid-sz7xmlte] a[data-astro-cid-sz7xmlte]:hover{color:#fff}.footer-disclaimer[data-astro-cid-sz7xmlte]{padding:24px 0;border-bottom:1px solid #1e293b;color:#94a3b8;font-size:.82rem;line-height:1.55}.footer-disclaimer[data-astro-cid-sz7xmlte] p[data-astro-cid-sz7xmlte]{margin:.6em 0}.footer-bottom[data-astro-cid-sz7xmlte]{display:flex;justify-content:space-between;align-items:center;padding-top:22px;color:#94a3b8;font-size:.85rem;flex-wrap:wrap;gap:12px}.footer-legal[data-astro-cid-sz7xmlte]{display:flex;gap:18px}@media(max-width:1000px){.footer-grid[data-astro-cid-sz7xmlte]{grid-template-columns:repeat(2,1fr)}}@media(max-width:600px){.footer-grid[data-astro-cid-sz7xmlte]{grid-template-columns:1fr;gap:24px}}